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KMID : 0350519950480020395
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Journal of Catholic Medical College
1995 Volume.48 No. 2 p.395 ~ p.405
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Influence of Cyclosporin A on Compensatory Renal Growth in Unilateral Nephrectomized Rats
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Abstract
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It has been reported that adaptive increase in glomerular filtration rate after transplantation is diminished in patients who receive cyclosporin A (CsA) treatment, and this phenomenon is in part related to the inhibition of compensatory renal
growth by
CsA. However, experimental studies supporting inhibitory action of compensatory renal growth by CsA are variable according to animal species, CsA dosage and duration of CsA administration.
Therefore, this study was designed to evalulate the influence of CsA on compensatory renal growth in single kidney model which is comparable to the transplanted kidney. Compensatory renal growth was defined as contralateral kidney weight gain (KW
index)
and increase in proliferating cell nuclear antigen (PCNA)-positive cells (PCNA index) after unilateral nephrectomy. Following two groups were studied : 1) Control group (unilateral nephrectomized rats treated with vehicle, n=42) : 2) CsA group
(unilateral nephrectomized rats treated with CsA, n=42). CsA was administered intramuscuiarly at 50 mg/kg/day immediately after unilateral nephrectomy up to the end of the study. Following unilateral nephrectomy, the animals were sacrificed at 0,
12,
24, 48, 72, 120 and 168 hours. The changes of KW index and PCNA index between two groups were evaluated according to time interval.
@ES The results were as follows :
@EN 1. The KW indicies of two groups showed significant change according to time interval (P=0.0015). Between two groups, the KW index of CsA group was lower than control group at hour 120 and 168 (P<0.01, respectively).
2. In the cortex, the PCNA indicies of two groups showed significant change according to time interval (P=0.0001). Between two groups, the PCNA index of CsA group was lower than control group at hour 12, 24, 48, 72, 120, 168 (P<0.01,
respectively). In
the medulla and glomeruli, the PCNA indices of two groups showed no significant change during study period.
These findings demonstrate that CsA inhibits compensatory renal growth in single kidney model, and inhibition of cellular proliferation by CsA occurs in proximal convoluted tubules of cortex
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